Explore the scientific evidence on non-invasive high-flow generator ventilation in different application areas
- WHO Global. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. World Health Organization 2020.
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- Mc Enery T et al. COVID-19: Respiratory support outside the intensive care unit. Lancet Respir Med 2020. Available online 9 April 2020.
- Dowload file
- Nishkantha A. Use of non-invasive ventilation for patients with COVID-19: a cause for concern? Lancet Respir Med 2020. Published Online April 20, 2020.
- Dowload file
- KEY ADVANTAGES OF NON INVASIVE VENTILATORS (NIV)
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- Longhini F et al. High-Flow Oxygen Therapy After Noninvasive Ventilation Interruption in Patients Recovering From Hypercapnic Acute Respiratory Failure: A Physiological Crossover Trial. Crit Care Med. 2019 Jun;47(6):e506-e511.
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- Spoletini G et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: A pilot randomized controlled trial. J Crit Care. 2018 Dec;48:418-425.
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- M.L. Vega, L.Pisani Nasal high flow oxygen in acute respiratory failure
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- Mauri T et al. Nasal High Flow: Physiology, Efficacy and Safety in the Acute Care Setting, a Narrative Review. Open Access Emerg Med. 2019 May 29;11:109-120.
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- Möller W et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol (1985). 2015 Jun 15;118(12):1525-32. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
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- Mündel T et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
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- Ni YN et al. High-Flow Nasal Cannula Reduce the Rate of Reintubation in Adult Patients After Extubation? A Meta-Analysis. BMC Pulm Med. 2017 Nov 17;17(1):142.
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- Ni YN et al. The Effect of High-Flow Nasal Cannula in Reducing the Mortality and the Rate of Endotracheal Intubation When Used Before Mechanical Ventilation Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation. A Systematic Review and Meta-Analysis. Am J Emerg Med. 2018 Feb;36(2):226-233.
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- Spoletini G et al. Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest. 2015 Jul;148(1):253-261.
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- Van Hove SC et al. An Experimental and Numerical Investigation of CO2 Distribution in the Upper Airways During Nasal High Flow Therapy. Ann Biomed Eng. 2016 Oct;44(10):3007-3019.
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- Goligher EC & Slutsky AS. Not Just Oxygen? Mechanisms of Benefit from High-Flow Nasal Cannula in Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2017 May 1;195(9):1128-1131.
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- Ni YN et al. Can High-flow Nasal Cannula Reduce the Rate of Endotracheal Intubation in Adult Patients With Acute Respiratory Failure Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation?: A Systematic Review and Meta-analysis. Chest. 2017 Apr;151(4):764-775.
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- Rochwerg E et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017 Aug 31;50(2):1602426.
- Go to link
- Biselli PJC. Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study. J Appl Physiol (1985). 2017 Jan 1;122(1):82-88.
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- Cortegiani A et al. High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial. Trials. 2019 Jul 22;20(1):450. doi: 10.1186/s13063-019-3514-1.
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- Pisani L et al. Change in Pulmonary Mechanics and the Effect on Breathing Pattern of High Flow Oxygen Therapy in Stable Hypercapnic COPD. Thorax. 2017 Apr;72(4):373-375.
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- Pisani L & Vega ML. Use of Nasal High Flow in Stable COPD: Rationale and Physiology. COPD. 2017 Jun;14(3):346-350.
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- Pisani L et al. Effects of High-Flow Nasal Cannula in Patients With Persistent Hypercapnia After an Acute COPD Exacerbation: A Prospective Pilot Study. BMC Pulm Med. 2020 Jan 13;20(1):12.
- Download file
- Storgaard LH. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018 Apr 16;13:1195-1205.
- Download file
Frequently
asked questions
How long did it take you to build the first prototype?
One of the questions we get asked most often is this one.
For the definition of an IBD prototype it took 5 weeks to build.
What do I do if Biorespira returns error E1?
Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E2?
- Check that the oxygen in the O2 cylinder has not finished;
- Check that the cylinder/wall outlet O2 valve is open;
- Check that the oxygen tube is not bent;
- Check the connection of the oxygen cylinder and tube;
- Check that the oxygen system which Biorespira is connected to delivers at least 0.7 bar;
- Check that the Flow and % of Oxygen are set correctly. 100% Oxygen can be set with a maximum of 50 litres per minute. Check the Oxygen and Flow setting modes in the manual;
- Press the RESET and then START buttons to return to therapy.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E3?
Was the error given within the first 5 minutes of therapy?
NO: contact technical support on the freephone number indicated in the footer of the website.
YES:
- Check that the oxygen in the O2 cylinder has not finished;
- Check that the cylinder/wall outlet O2 valve is open;
- Check that the oxygen tube is not bent;
- Check the connection of the oxygen cylinder and tube;
- Check that the oxygen system which Biorespira is connected to delivers at least 0.7 bar;
- Check that the Flow and % of Oxygen are set correctly. 100% Oxygen can be set with a maximum of 50 litres per minute. Check the Oxygen and Flow setting modes in the manual;
- Press the RESET and then START buttons to return to therapy.
If the problem persists, contact technical support
What do I do if Biorespira returns error E4?
Check that the air inlet on the inlet filter side is not blocked.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E5?
- Start therapy with the lowest PEEP and then increase it to the tolerated value;
- Check that the Biorespira air outlet tube is not bent;
- Check that the Biorespira air outlet tube is not blocked;
- Press the RESET and then START buttons to return to therapy.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E6?
- Check that the pressure of the oxygen circuit does not exceed 6 bar;
- Restart the machine and set the therapy with an O2 % greater than 25%;
- Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E7?
- Check that the PEEP tube is not bent or broken;
- Check that the PEEP tube is connected correctly on both sides;
- Check for leaks on the helmet/other interfaces;
- Check that all the tubes are connected correctly to the helmet, at the inlet and outlet;
- Do not disconnect the helmet tube and/or PEEP tube while treatment is in progress;
- Check that the helmet/other interfaces are of the correct size;
- Make sure the patient is cooperative and there is no change in the state of consciousness;
- Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E8?
Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E9?
- Check the electrical connection of the device;
- Turn off the device, wait 120 seconds and then turn it back on;
- Do not turn off or disconnect the power supply while the machine is in therapy;
- Verify that there has not been a temporary power outage;
- Resume the therapy and set the parameters again.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E10?
The battery may have discharged excessively. Keep the device on in alarm mode for 30 minutes to allow the battery to recharge, and try again.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E11?
Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E12?
- Make sure that neither the outlet filter nor the respiratory circuit are connected and that the dust filter is inserted correctly;
- Make sure that the inlet filter is in place and inserted correctly;
- Make sure that the Biorespira air inlet is not blocked;
- Make sure that the Biorespira air outlet is not blocked;
- Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira returns error E13?
- Turn off the device and make sure that the PEEP pressure tube is not connected at start-up.
- Turn off and restart.
If the problem persists, contact technical support.
What do I do if I cannot turn on Biorespira?
- Check that the power supply socket is connected properly to the wall;
- Connect the power supply to another socket/check that the socket supplies power by connecting another electronic device;
- Check that the power supply on Biorespira is connected correctly;
- Replace the power supply;
- Turn off and restart.
PLEASE NOTE: The green light on the power supply must be ON to indicate proper operation.
If the problem persists, contact technical support.
What do I do if Biorespira starts up but freezes on the logo screen?
Turn off and restart.
If the problem persists, contact technical support.
What do I do if Biorespira starts up correctly but the screen does not hear the commands?
- Clean the screen and try again;
- Turn off and restart.
If the problem persists, contact technical support.